| Date | Opponent / Event | Location | Time / Result | Media | Â |
|
| 10/15/10 | 2010 Red Storm Tip-Off | Queens, N.Y. (Carnesecca Arena) | 7:00 p.m. ET | TV: ESPNU | More |
| 11/02/10 | 2010 St. John's Basketball Media Day | Queens, N.Y. (Taffner Field House) | 2:45 p.m. ET | | More |
| 11/06/10 | vs. Westmont | Queens, N.Y. (Carnesecca Arena) | W, 100-42 | | More |
| 11/16/10 | at Saint Mary's | Moraga, Calif (McKeon Pavilion) | L, 76-71 | TV: ESPN | More |
| 11/17/10 | vs. Columbia | Queens, N.Y. (Carnesecca Arena) | W, 79-66 | | More |
| 2010 Carrs/Safeway Great Alaska Shootout |
| 11/25/10 | vs. Ball State | Anchorage, Alaska (Sullivan Arena) | W, 78-73 (OT) | TV: MSG Plus | More |
| 11/26/10 | vs. Drake | Anchorage, Alaska (Sullivan Arena) | W, 82-39 | TV: MSG Plus | More |
| 11/28/10 | vs. Arizona State | Anchorage, Alaska (Sullivan Arena) | W, 67-58 | TV: MSG Plus | More |
|
| 12/01/10 | vs. Wagner | Queens, N.Y. (Carnesecca Arena) | W, 69-61 | | More |
| 12/07/10 | vs. St. Bonaventure | Queens, N.Y. (Carnesecca Arena) | L, 67-66 | TV: SNY | More |
| 12/11/10 | at Fordham | Bronx, N.Y. (Rose Hill Gym) | L, 84-81 | TV: YES Network | More |
| Madison Square Garden Holiday Festival |
| 12/20/10 | vs. Davidson | New York, N.Y. (Madison Square Garden) | W, 62-57 | TV: MSG | More |
| 12/21/10 | vs. Northwestern | New York, N.Y. (Madison Square Garden) | W, 85-69 | TV: MSG | More |
|
| 12/29/10 | at West Virginia * | Morgantown, W.Va. (WVU Coliseum) | W, 81-71 | TV: SNY | More |
| 01/01/11 | at Providence * | Providence, R.I. (Dunkin' Donuts Center) | W, 67-65 | TV: SNY | More |
| 01/03/11 | vs. No. 13/13 Georgetown * | New York, N.Y. (Madison Square Garden) | W, 61-58 | TV: ESPN2 | More |
| 01/08/11 | at No. 14/15 Notre Dame * | Notre Dame, Ind. (Purcell Pavilion) | L, 76-61 | TV: ESPNU | More |
| 01/12/11 | vs. No. 4/4 Syracuse * | New York, N.Y. (Madison Square Garden) | L, 76-59 | TV: ESPNU | More |
| 01/16/11 | vs. No. 9/11 Notre Dame * | New York, N.Y. (Madison Square Garden) | W, 72-54 | TV: MSG | More |
| 01/19/11 | at No. 19/15 Louisville * | Louisville, Ky. (KFC Yum! Center) | L, 88-63 | TV: SNY | More |
| 01/22/11 | vs. No. 25/RV Cincinnati * | Queens, N.Y. (Carnesecca Arena) | L, 53-51 | TV: SNY | More |
| 01/26/11 | at No. 21/20 Georgetown * | Washington, D.C. (Verizon Center) | L, 77-52 | TV: SNY | More |
| 01/30/11 | vs. No. 3/3 Duke | New York, N.Y. (Madison Square Garden) | W, 93-78 | TV: CBS | More |
| 02/02/11 | vs. Rutgers * | Queens, N.Y. (Carnesecca Arena) | W, 58-56 | TV: SNY | More |
| 02/05/11 | at UCLA | Los Angeles, Calif. (Pauley Pavilion) | L, 66-59 | TV: CBS | More |
| 02/10/11 | vs. No. 10/9 Connecticut * | New York, N.Y. (Madison Square Garden) | W, 89-72 | TV: ESPN | More |
| 02/13/11 | at Cincinnati * | Cincinnati, Ohio (Fifth Third Arena) | W, 59-57 | TV: MSG | More |
| 02/15/11 | at Marquette * | Milwaukee, Wis. (Bradley Center) | W, 80-68 | TV: ESPNU | More |
| 02/19/11 | vs. No.4/4 Pittsburgh * | New York, N.Y. (Madison Square Garden) | W, 60-59 | TV: ESPN | More |
| 02/23/11 | vs. Depaul * | Queens, N.Y. (Carnesecca Arena) | W, 76-51 | TV: MSG Plus | More |
| 02/26/11 | at No. 15/14 Villanova * | Philadelphia, Pa. (Wells Fargo Center) | W, 81-68 | TV: ESPN | More |
| 03/03/11 | at Seton Hall * | Newark, N.J. (Prudential Center) | L, 84-70 | TV: ESPN2 | More |
| 03/05/11 | vs. USF * | Queens, N.Y. (Carnesecca Arena) | W, 72-56 | TV: MSG | More |
| BIG EAST Championship |
| 03/09/11 | vs. Rutgers (BIG EAST Second Round) * | New York, N.Y. (Madison Square Garden) | W, 65-63 | Interactive Bracket TV: ESPN | More |
| 03/10/11 | vs. No. 11/11 Syracuse (BIG EAST Quarterfinals) | New York, N.Y. (Madison Square Garden) | L, 79-73 | Interactive Bracket TV: ESPN | More |
|
| NCAA Championship |
| 03/17/11 | vs. Gonzaga (NCAA Second Round) | Denver, Colo. (Pepsi Center) | L, 86-71 | NCAA Central TV: CBS | More |
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